Again, the answer to this question varies from company to company. And again, testing is the way to find out what works best. Typically, weekends and mornings seem to be times when multiple emails are opened, but since your audience may have different habits, it's best to experiment and then use your data to decide.
It made me wonder, how damaging would it be for an active business? A few hours of downtime costs real money. For me it costed only time.
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